Parietal cell hyperplasia induced by long-term administration of antacids to rats.

Parietal cell hyperplasia induced by long-term administration of antacids to rats.

Suspension of magnesium and aluminum hydroxide (30--60 mEq/24h) or a comparable volme of water was orally administered by gastric intubation to two groups of 20 male Wistar rats each over 60 days. The antacid treatment led to a significant increase in the height (0.464 +/- 0.02 mm v. 0.318 +/- 0.06) and in the volume (472 +/- 32 mm3v.328 +/- 45) of the fundic mucosa of the stomach, in the avera...

Analysis of cell hyperplasia and parietal cell dysfunction induced by Ostertagia ostertagi infection

Infections in cattle with the gastric nematode Ostertagia ostertagi are associated with decreased acid secretion and profound physio-morphological changes of the gastric mucosa. The purpose of the current study was to investigate the mechanisms triggering these pathophysiological changes. O. ostertagi infection resulted in a marked cellular hyperplasia, which can be explained by increased trans...

Cognitive deficits induced in young rats by long-term corticosterone administration.

Corticosterone slow-release pellets, implanted for 9 weeks in young Fischer 344 rats, resulted in continuous high plasma levels of the hormone which are comparable to those of rats under mild stress. One week following termination of the drug treatment, the rats were tested in an eight-arm radial maze. During the initial acquisition stages, corticosterone-treated rats exhibited cognitive impair...

Subcutaneous lipoatrophy induced by long-term pegvisomant administration.

Neuronal damage of the dorsal hippocampus induced by long-term right common carotid artery occlusion in rats

Objective(s):The present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (UCO) on the dorsal hippocampal neurons in rats. Materials and Methods:Sixty four male Sprague-Dawley rats aged 4 months were divided into two groups of sham and UCO. These two groups were further divided into 4 sets of histopath...